STUDY AMOUNTS / NOT PERSONAL ADVICE
NAD+ Dosage: What studies gave, not what to take
The trials list pill and IV NAD+ amounts. They also show how long blood changes lasted and what people felt.
What these amounts can and can't tell you
Published studies gave set amounts and watched what followed. They tested NAD+ drips and two pill ingredients that help your cells build NAD+. The list tells you the amount, how people received it, and how long each study ran. It also tells you how fast the body cleared it. I'd treat every amount here as a study fact, because none of these trials knows your health, your medicines, what your doctor has told you, or why you're asking today.
A study amount isn't your plan.
What amounts the NAD+ studies used
Most NAD+ pill studies gave a part the body can use, not whole NAD+. Far fewer tested drips into a vein. Here are the amounts from those papers.
- Pill ingredient NMN: Human trials used 250-900 mg/day. Researchers tried 250 mg/day more than once [1]. Another trial compared 300/600/900 mg/day and favored 600 mg/day for its blood result [3].
- Pill ingredient NR: Trials often used 250-1000 mg/day. One split the group across 100/300/1000 mg/day. The blood increases were 22%/51%/142% [4]. Safety work has gone up to 3000 mg/day.
- NAD+ by IV: Reports describe about 250-1000 mg at one visit, spread across hours. One blood test used 750 mg over 6 hours [6]. One thinking test used 750 mg/day for 5 days in a row [9].
- Nicotinamide, a vitamin form: Other work used 500 mg twice daily. Skin work placed it on the skin [12].
These figures don't pick an amount for you. You can't turn the list into your schedule.
What NAD+ does after a pill or IV drip
How long NAD+ lasts depends on how it reaches your body. In the 6-hour IV study, blood tests couldn't find whole NAD+ for about the first 2 hours. The body had already broken much of it into other parts found in urine [6]. An IV amount doesn't sit in your blood as whole NAD+. That group can't tell you how fast your own body would clear it.
The two pill ingredients act in another way. Your body takes them in and uses them to build NAD+. During 8-to-12-week trials, blood levels stayed raised while people kept taking daily pills [3][4]. Their bodies built the NAD+; they didn't swallow it whole.
What side effects people had in NAD+ studies
The way people received NAD+ changed the side effects. The pill ingredient NR at 100-1000 mg/day for 8 weeks caused no more problems than an inactive pill, called a placebo. It also caused no flushing [4]. An NMN study saw no safety problem at 300-900 mg/day across 60 days [3]. A second NMN study at 250 mg/day found no change in weight, fat, or muscle [1].
IV NAD+ brought more trouble. Faster flow could cause chest or belly pain, flushing, and nausea. The 750 mg paper noted chest tightness and belly pain at higher rates [6]. Clinic records compared IV NAD+ at 500 mg with IV NR at 500 mg. NAD+ went with moderate or severe stomach trouble, faster heartbeats, and chest pressure. The average visit lasted 97 minutes. NR brought mild tingling, and its average visit lasted 37 minutes [15]. Your own side effects could differ.
Two other concerns matter. The FDA ordered its gravest type of recall after a compounded NAD+ shot held too much poison made by bacteria. Scientists also ask whether extra NAD+ could help an existing cancer get energy. They don't know if that happens in people [14]. If you've had cancer or have it now, ask the doctor treating you what this unknown means for your care.
What changes with pills, drips, and shots
Most fair human tests gave the two pill ingredients or another vitamin form. The IV work comes only from small studies or past clinic notes [6][9][15]. Shots into skin or muscle have almost no published human work. Patches, nose sprays, forms held under the tongue, and skin products also lack good tests.
Storage matters too. NAD+ and the pill ingredient NMN pull in water. Hot or wet air may spoil them. Mixed NAD+ for a shot must stay cold and out of the light. Compounded shots also carry the risk of poison made by germs [14]. I'd want the clinic to tell you how your product was stored.
Why this page can't tell you how much NAD to take
Human trials gave NMN at 250-900 mg/day [1][3]. NR work used 250-1000 mg/day, with up to 3000 mg/day checked for safety [4]. IV reports describe roughly 250-1000 mg at a visit [6][9]. These study amounts can't weigh your health, your medicines, or why you're asking. They aren't your plan.
Someone still has to ask whether NAD+ makes sense for you. At Promise Peptides (mypromise.com), NAD+ requires a prescription that a licensed clinician may write after evaluating you. The study amounts above can't do that work.
Why studies don't give a best time of day
No trial picked morning over night. One body process used to make NAD+ follows your daily clock and changes with exercise [5]. That fact can't choose an hour for NAD+ or either pill ingredient. Any claim about perfect timing reaches past these studies.